Solid Phase Synthesis of Side-Chain Cross-Linked Peptide Oligomers

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

S Mukherjee, M Fang, WM Kok, EA Kapp, VJ Thombare, R Huguet, CA Hutton, GE Reid, BR Roberts

2019-10-01

Dityrosine cross-linking of Aβ peptides and α-synuclein is increasingly becoming recognized as a biomarker of neuropathological di..

Radiosynthesis and preliminary: In vivo evaluation of 18F-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis

MB Haskali, D Denoyer, PD Roselt, RJ Hicks, CA Hutton

2019-01-01

Duramycin derivatives incorporating an [¹⁸F]-labelled prosthetic group and one or two hydrophilic sugar amino acid moie..

Bridged bicyclic peptides: Structure and function

VJ Thombare, CA Hutton

2018-05-01

Bicyclic peptides are conformationally rigid molecules that can bind with high affinity and specificity to their protein target, y..

Recent developments in radiolabelled peptides for PET imaging of cancer

CL Charron, AL Farnsworth, PD Roselt, RJ Hicks, CA Hutton

2016-01-01

This digest highlights recent developments in the field of molecular imaging of cancer using peptide-based targeting entities. Syn..

A general method for interconversion of boronic acid protecting groups: Trifluoroborates as common intermediates

QI Churches, JF Hooper, CA Hutton

2015-06-05

We have developed a general protocol for the interconversion of diverse protected boronic acids, via intermediate organotrifluorob..

A new method for peptide synthesis in the N→C direction: amide assembly through silver-promoted reaction of thioamides

A Pourvali, JR Cochrane, CA Hutton

2014-11-20

The Ag(i)-promoted coupling of amino acids and peptides with amino ester thioamides generates peptide imides without epimerisation..